Highlights of Gringo Trail

La Paz is the administrative capital of Bolivia and at 3,600 metres is the highest capital city in the world. La Paz is nestled in a steep canyon on the Bolivian Altiplano, underneath the peak of Mount Illimani. La Paz was founded in the 16th century due to a nearby discovery of gold deposits and although the gold boom didn't last, its strategic location along the silver route ensured its prosperity. La Paz is characterised by spacious plazas, cobblestone streets and narrow alleyways, with its colourful markets being a major attraction. With a large indigenous population, the markets of interest include the Witches' Market selling potions and incantations made from herbs, seeds and other products, the Carnaval market selling colourful costumes and numerous shops selling ponchos, gloves and hats made from alpaca wool. Buildings of note in La Paz include the Palacio Legislatico, the San Francisco Cathedral and the Museo National del Arte.

Tiwanaku

The ruins at Tiwanaku near La Paz are Bolivia's largest archaeological site and the remains of the capital of powerful pre-Hispanic empire extending over northern Bolivia, southern Peru, northern Chile and north-western Argentina. Initially settled around 1200 BC, the empire reached its apogee between 500 and 900 AD and is distinct from other pre-Hispanic empires in the Americas. The Temple of Akapana and the Gate of the Sun are the most notable structures found at Tiwanaku.

UNESCO World Heritage Site: Tiwanaku: Spiritual and Political Centre of the Tiwanaku Culture

Potosí

The biggest silver lodes in the Americas were discovered in Cerro de Potosi, the mountain overlooking the city, in 1542 and the site soon became the world's largest industrial complex, producing more than half of the silver found in the continent. The silver production made the town one of the wealthiest in Latin America and fuelled the Spanish economy for almost 300 years. The human cost was horrific however, with an estimated 8 million people (indigenous and African slaves) dying in the mines. It's possible to visit the mines today, still used to extract tin, but it is an uncomfortable and distressing, though enlightening experience. Conditions for the miners are still difficult but are now much fairer as it is run as a co-operative. The silver wealth ensured that Potosi was one of the most beautiful colonial cities in the Americas and much of that heritage still exists today. The highest city in the world at 4,090 metres, Potosi has some grand colonial architecture and numerous ornate Baroque churches. Buildings of note include the Church of San Lorenzo, the Convent of Santa Teresa and the Casa de la Moneda, the original 18th century royal mint which is now a museum.

UNESCO World Heritage Site: City of Potosí

Historic City of Sucre

The colonial city of Sucre was founded in 1538 as La Plata and was the first capital of Bolivia. The city's name was changed to Chuquisaca in 1776 and later to Sucre in honour of the general who fought for Bolivian independence. The House of Freedom is Sucre is one of the country's most important historical monuments, where many of the keys events in the independence struggle took place. Today Sucre is the cultural and education centre of Bolivia, with a host of historic buildings and museums. Its 16th-century religious buildings include San Lázaro, San Francisco and Santo Domingo while the Cathedral contains the jewel encrusted ‘Virgen do Guadalupe’ by Bernardo Britti. The colonial ambience and student culture make Sucre a great city to explore and enjoy while the surrounding countryside is ideal for hiking, mountain biking and horse riding.

UNESCO World Heritage Site: Historic City of Sucre

Amazon Rainforest (Bolivia)

The rainforest of the Amazon Basin extends over vast areas of the north-east of Bolivia. This is a region of enormous biodiversity of flora and fauna, with hundreds of species of birds and butterflies in addition to animals such as shy tapir, jaguar, howler monkey, deer and sloth. The region includes the protected areas of the Madidi National Park and the Noel Kempff Mercado National Park, the latter a UNESCO World Heritage Site. Staying in jungle lodges, you can explore the Amazon with walks through the rainforest and canoe rides along the rivers, spotting wildlife and learning about the importance and uses of the jungle plants.

UNESCO World Heritage Site: Noel Kempff Mercado National Park

Salar de Uyuni

The Salar de Uyuni, or Great Salt Desert, in south-western Bolivia is the world's largest and highest salt flats and one of Bolivia's most spectacular natural features. The salt lake covers some 12,000 km² at an altitude of 1,650 metres and the contrast between the bright blue skies and the blindingly white salt crust is spectacular. Three to four day tours of the region can be taken in 4x4s to explore the remarkable landscape and various sites of interest. In addition to taking the compulsory perspective defying photos, you can visit the village of Jirira at the foot of the Tunupa Volcano and explore the natural caves on the volcano, the volcanic Fish Island home to some enormous cacti and a salt works to learn of the extraction process. Other natural features of interest include Laguna Colorado, a bright red lake and Laguna Verde, a striking blue-green lake, which are coloured by algae and rich minerals and the geysers and thermal baths of Sol de Manana.

San Pedro de Atacama

The oasis town of San Pedro de Atacama is a base for exploring the dramatic natural features of the Atacama Desert in the north of Chile. San Pedro itself is a charming little town of white-washed buildings, dusty streets, some great restaurants and bars and countless travel companies offering tours of the surrounding region. The Valley of the Moon is a bizarre, lunar-like landscape with strange rock formations. Even amongst the crowds, watching the sunset here is a magical experience. Elsewhere the Salar de Atacama is the world's largest salt lake, its rich mineral deposits attracting many flamingos and other birds. The Geysers of El Tatio, located at 4,500 metres and surrounded by volcanoes, are best visited in the morning to see the water and steam hurling up from the geysers, thermal wells and fumaroles, with the morning light producing a magical effect. Other options in the area include scaling up and sand boarding down the sand dunes of Death Valley, visiting the Puritama hot springs and hiking some of the nearby volcanoes.

Quebrada de Humahuaca

The Quebrada de Humahuaca (Humahuaca Gorge) is located in northern Argentina along the valley of the Rio Grande from its source in the High Andes to its confluence with the Rio Leone 150km to the south. It has been a major cultural and trade route for thousands of years, known as the Camino Inca, and was used for 200 years to transport the silver mined at Potosi back to Spain. The valley features traces of several historical periods, from prehistoric hunter-gatherer communities, to the Inca Empire of the 15th and 16th centuries and the fight for independence in the 19th and 20th centuries. The scenery is this region is spectacular and the villages of Purmamarca, Humahuaca and Uquia are picturesque settlements in beautiful mountainous settings.

UNESCO World Heritage Site: Quebrada de Humahuaca

Salta

Salta is Argentina's colonial gem, a 16th century city with some magnificent historical buildings and set in a beautiful region that offers the chance to indulge in many activities. Salta's highlights include the 18th century Cabildo Historico (old town hall) and the 19th century cathedral, both on the main plaza, as well as the 16th century San Bernardo Convent and the gaudy facade of the Iglesia San Francisco with its huge spire. The cable car up to San Bernardo Hill affords superb views over the city and its surrounds. Salta also has a vibrant restaurant and bar scene, particularly in the Balcarce quarter. From Salta, many activities can be arranged in the surrounding area, including white-water rafting, abseiling, bungee jumping, paragliding and horse riding.

Cordoba is Argentina's second largest city and a university town with a strong colonial history, dating back to its founding in 1573. The Jesuit Block in Cordoba is a UNESCO World Heritage Site, comprising the university built around a central open space with a colonnaded courtyard, the huge domed church of the Society of Jesus with its richly decorated interior and the college. These buildings demonstrate the fusion of European and indigenous culture from this key period in Argentine history. The World Heritage Site also includes the Jesuit estancias of Jesus María and Santa Catalina outside the city. Cordoba's large student population (there are seven universities here) mean the city has a vibrant atmosphere and great nightlife. Just outside Cordoba lies Alta Gracia, where the young Ernesto Guevara lived - his former house has been converted into a museum focusing on his early life.

UNESCO World Heritage Site: Jesuit Block and Estancias of Córdoba

Mendoza is one of Argentina's most popular cities for travellers, who are attracted to its laid back atmosphere, wide leafy avenues and lively cafe and bar-laden plazas. The Mendoza region produces 70% of the wine made in Argentina and it's a great place to tour some of the major wineries and do wine tasting, particularly of the Malbec grape unique to Argentina. The spectacular mountainous landscapes around Mendoza are also ideal for trekking and horse riding.

Santiago

Chile's capital is a vast and busy city located underneath the Andes mountains. Its historic buildings of note include the Presidential Palace, the historic main square Plaza de Armas, the Cathedral, the monastery of San Francisco and the Palacio de la Real Audiencia, which houses the National History Museum. On a clear day, the views from Cerro San Cristobal in Parque Metropolitano are excellent - where the Andes peaks tower over the city. The bohemian Bellavista district is a popular spot with many restaurants, bars and nightclubs, as well as the unusual house of the Chilean poet and Nobel Prize winner Pablo Neruda.

Buenos Aires

Buenos Aires is one of the great cities of South America - a vibrant, cosmopolitan and culturally fascinating metropolis. It has a strong European influence borne from large scale immigration from Spain, Italy and France and some excellent and grandiose 19th century architecture along its wide avenues. Buenos Aires has several distinctive neighbourhoods. San Telmo is the artists quarter with some great restaurants and bars and a wonderful Sunday market. The Italian barrio of La Boca is famous for its colourfully painted buildings, street tango shows and the passion and spectacle of the football games of the Boca Juniors team. Palermo and Recoleta are the fashionable districts, the latter famous for the grandiose tombs at La Recoleta Cemetery, resting place of Eva Peron. Back in the city centre, Plaza de Mayo is surrounded by important historical buildings including the presidential palace, site of the mass demonstrations in support of Peron in 1945. It is at night when Buenos Aires comes alive though, with the bars, tango shows and nightclubs keeping the city pulsating until the early hours.